AbstractG Protein coupled receptors
AbstractG Protein coupled receptors (GPCRs) constitute the largest family of cell surface receptors and drug targets. GPCR signalling and desensitization is critically regulated by arrestins (arr). GPCR arr interaction is biphasic where the phosphorylated carboxyl terminus of GPCRs docks to the N domain of arr first and then seven transmembrane core of the receptor engages with arr.
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